The Knoxville Fire Department responded to a call about a residential fire near Clinton Highway on Friday afternoon.
KFD responded to a call from a neighbor around 1:50 p.m. at 608 Metler Dr.
Firefighters reported that they arrived on the scene to find flames coming through the front and back windows of the house.
After flames were extinguished, KFD reported that one victim was found dead in the home.
The victim was identified by authorities as 38-year-old Kristin Howerton.
Arson investigators are on the scene to determine the cause.